Combined Effects of Cadmium- and Cyanide-Contaminated Diet on Oxidative Stress Biomarkers in Different Tissues of Rats

Background. Several toxicants present simultaneously in the environment have combined toxicological effects. In addition, various xenobiotics distinct effects on oxidative stress biomarkers animal cells and tissues.
 The aim of this study was to analyze effect cadmium (Cd) cyanide (CN) through food chain some antioxidant indices tissues (lungs, testes, heart, brain) male Wistar rats.
 Materials Methods. included sixty African catfish allocated four groups, each comprising fifteen fish, treated with potassium (KCN) chloride (CdCl2), held at a temperature 25°C 100-litre fish tank aquarium water contaminated 0.4 mg both cadmium/100 ml water. All were later killed, dried, used prepare diet for experimental animals. Twenty rats divided into five rats, as well, fed 28 days follows: Group A - control diet; B cyanide-contaminated C cadmium-contaminated D + cadmium. Subsequently, they sacrificed. Biochemical analysis excised from done.
 Results. There significant (p < 0.05) increase lipid peroxidation level decrease superoxide dismutase, catalase reduced glutathione activities lungs, brain containing compared controls. altered acetylcholinesterase activity brain, peroxidase activity, glutathione-S-transferase reductase Conclusions. Cadmium cyanide, via chain, induce rats.